| Title | An fMRI study of multimodal semantic and phonological processing in reading disabled adolescents
| | Authors | Nicole Landi, W. Einar Mencl, Stephen J. Frost, Rebecca Sandak, Kenneth R. Pugh
| | Journal | Annals of Dyslexia, Volume 60, Number 1, 2009, pp. 102-121
| | Year of publishing | 2009
| | Abstract | Using functional magnetic resonance imaging, we investigated multimodal (visual and auditory) semantic and unimodal (visual only) phonological processing in reading disabled (RD) adolescents and non-impaired (NI) control participants. We found reduced activation for RD relative to NI in a number of left-hemisphere reading-related areas across all processing tasks regardless of task type (semantic vs. phonological) or modality (auditory vs. visual modality). Moreover, activation differences in these regions, which included the inferior frontal gyrus, the superior temporal gyrus, and the occipitotemporal region, were largely independent of in-scanner performance in our auditory semantic task. That is, although RD participants and NI participants differed in performance in visually presented conditions, they did not differ significantly in the auditory condition, yet similar patterns of reduced activation were observed in these regions across conditions. These findings indicate a neurobiological marker in RD that is independent of task, modality, or performance. These findings are discussed in the context of current neurobiological models of RD.
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